Abstract: Physical restraint is a piece of equipment or device that restricts a patient's ability to move. Restraints may keep a patient from getting out of bed or moving arms and legs excessively. The aim of this study was to establish, apply basic guidelines for nurses that dealing with restrained patients and evaluate the effect of physical restraint guidelines on nurse's performance. Methods A Quasi experimental research design was used in this study. Sample all nurses (90) that dealing with physical restraint patients were selected from the Mansoura University Hospitals. Five tools were used for data collection. Results of the present study found that, the mean age of the nurses was 28.73 ± 6.91years. In addition to all of the studied nurses had unsufficient practices score and 84.4% of them had unsufficient knowledge score as pretest, while 78.9% of the subject study had sufficient practice and 94.4% of them had sufficient knowledge after direct implementation physical restraint guidelines, on the other hand on the follow up phase the same study reveled that 63.3% of the nurses had sufficient practice while 76.7% had sufficient knowledge score regarding physical restraint application. The study concluded; there was significantly improvement in nurses' knowledge and practice concerning to physical restraint application after implementation of physical restraint guidelines.