Objective : The objective of the present study was to systemically evaluate the neurocognitive changes for two months after Whole brain radi­otherapy (WBRT) and to evaluate time to neurocognitive failure using different reported mini-mental state examination (MMSE) cutoff score points (age/education and 23). Pa­tients and methods: This study was conducted in Mansoura University Hospital (years 2007 & 2008) on 24 patients, 16 males and 8 females aged >18 years with more than 2 brain metastases. They received WBRT at a dose of 30 Gy in 10 equal daily fractions. Overall survival (OAS) measured from the date the patient first seen to the date of death or the date the patient was last known to be
alive. The Folstein MMSE was done before, immediately and 2 months af­ter WBRT to evaluate neurocognitive progression. Time to neurocognitive failure was evaluated using 2 oft-reported cutoff score points. Results: The median survival time was 4.5 months. The OAS was 45% at 6 month, 25% at 1 year, and 8.3% at 1.5 years. The OAS for patients 65 year-old, however the dif­ference was statistically insignificant (p=0.21). 79.2% of patients devel­oped deterioration, while 12.5% showed stable and 8.3% only devel­oped improvement of cognitive func­tion at two month. There was mild statistically significant deterioration of basal MMSE value immediately after WBRT (p=0.047)