This study was performed to assess the effectiveness of some Sinai's Flora extracted from thyme (Origanum vulgare L.), castor (Ricinus communis Linn), common horehound (Marrubium vulgare L.) and yellow nutsedge (Cyperus esculentus L.) against the larvae of greater wax moth, Galleria mellonella and on honeybee workers. Plants were collected from Sinai Peninsula, Egypt, during the period from November 2018 to February 2019, dried and ground. Aqueous extracts were used at 10, 15, and 20% levels and contact toxicity assay was performed in the laboratory on the larvae of greater wax moth, Galleria mellonella. The test was set up in a Complete Randomized Design (CRD) with 10 replications of each plant extract. The results revealed that, plant extracts tested at various levels showed variable responses against the larvae of greater wax moth, Galleria mellonella compared to the controls. The highest larval mortality percentage (92.15%) was recorded. The lowest LC50 values were obtained from aqueous extract of O. vulgare (7.07 %) against larvae of greater wax moth. The lowest toxicity effect against adults of honeybees was obtained when treated with aqueous extract of C. esculentus (4.24%) at 10% concentration. Hence, it be concluded that thyme extract at 20% concentration is a good natural pesticide against greater wax moth.