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271394

A REVIEW OF THEOPHYLLINE'S PHARMACOLOGICAL INTERACTIONS WITH MEDICINAL HERBS

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Last updated: 04 Jan 2025

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Abstract

Theophylline (TPH) is a bronchodilator with a limited therapeutic index and high inter-individual pharmacokinetic (PK) variability. In this paper, the interactions between TPH and medicinal herbs recorded in the literature were summarized.  The  collected references in the analyzed literature were investigated. A decrease in TPH bioavailability by induction mechanism on CYP1A2 was reported during co-administration of herbs or herbal extracts as (Andrographis paniculata, Commiphora myrrha, Ephedra species, Evodia rutaecarpa, Lepidium sativum, Sophora flavescens, Salvia miltiorrhiza, and Trigonella foenum-graecum). TPH bioavailability was increased by inhibition mechanism on CYP1A2 when co-administered with herbs (Acacia catechu, Angelica species, Astragalus species, Cassia auriculata, Cardiospermum halicacabum  and  Scutellariae baicalensis. Meanwhile, concomitant use of TPH with (Cassia occidentalis, Glycyrrhiza glabra, Ginkgo biloba, Hypericum perforatum, Nigella sativa, Punica granatum and Rhodiola rosea) was reported to be insignificant. In this review, we focus on the interactions between TPH and medicinal herbs that haven't been covered in prior studies. To reduce the patients' health risks, health professionals involved in their treatment are expected to be thoroughly educated about the interactions between TPH and medicinal plants.

DOI

10.21608/bfsa.2022.271394

Keywords

Theophylline, Herb-drug interaction, CYP1A2, Pharmacology, bioavailability

Authors

First Name

Issam

Last Name

Abushammala

MiddleName

Mohammed

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al- Azhar University- Gaza, P.O Box: 1277, Gaza, Palestine.

Email

issam.abushammala@uv.es

City

-

Orcid

0000-0002-3371-4718

First Name

Abdallah

Last Name

Hamdan

MiddleName

Mohammed

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al- Azhar University- Gaza, P.O Box: 1277, Gaza, Palestine.

Email

abdhamdan83@gmail.com

City

-

Orcid

0000-0002-9178-5880

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-02-12

Publish Date

2022-12-01

Page Start

493

Page End

506

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 493-506.pdf

PDF . 842.9kB

Link

https://bpsa.journals.ekb.eg/article_271394.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271394

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271,394

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

A REVIEW OF THEOPHYLLINE'S PHARMACOLOGICAL INTERACTIONS WITH MEDICINAL HERBS

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Type

Article

Created At

22 Jan 2023