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239527

THE DIAGNOSTIC VALUE OF SERUM FERRITIN IN ASSESSING IRON STATUS IN SYRIAN HEMODIALYSIS PATIENTS

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Last updated: 25 Dec 2024

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Abstract

In this research, we aimed to study the diagnostic value of serum ferritin in assessing iron status in hemodialysis patients (HD). While ferritin is one of the most important laboratory parameters used to assess iron status, but the presence of confounding factors such as chronic inflammation in HD patients may confuse the interpretation of laboratory results. The study was conducted on 73 adult patients who were on maintenance HD at Al-Basel Hospital in Homs, Syria, with the presence of 25 age – matched healthy subjects. Blood samples were collected before the HD session, serum CRP was used as an inflammatory marker. The results showed a significant increase in serum ferritin values in the patients group compared to healthy subjects, with an average value of (539.64 ng/ml), and this increase coincided with a decrease in Hb and TSAT values,  but with an increase in CRP. Also, we found a significant positive correlation between ferritin and CRP (r2= 0.132, P= 0.002) in the patients group. Thus, the presence of chronic inflammation in HD patients may raise serum ferritin unrelated to iron stores, and reduce its diagnostic value.

DOI

10.21608/bfsa.2022.239527

Keywords

Anemia, Inflammation, Hemodialysis, C-reactive protein, ferritin

Authors

First Name

Marwa

Last Name

Hamdan

MiddleName

-

Affiliation

Department of Biochemistry and Microbiology, Faculty of Pharmacy, Al Baath, University, Homs, Syria

Email

mimi93hamdan@gmail.com

City

-

Orcid

0000-0003-4546-0580

First Name

Sulaf

Last Name

Alwassouf

MiddleName

-

Affiliation

Department of Biochemistry and Microbiology, Faculty of Pharmacy, Al Baath, University, Homs, Syria

Email

sulaf_alwassouf@yahoo.com

City

-

Orcid

-

Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2021-11-05

Publish Date

2022-06-01

Page Start

351

Page End

357

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 351-357.pdf

PDF . 757.6kB

Link

https://bpsa.journals.ekb.eg/article_239527.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=239527

Order

29

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

THE DIAGNOSTIC VALUE OF SERUM FERRITIN IN ASSESSING IRON STATUS IN SYRIAN HEMODIALYSIS PATIENTS

Details

Type

Article

Created At

22 Jan 2023