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SOLUBILIZATION AND STABILITY OF PYRIDINE-3-CARBOXALDHYDE THIOSEMICARBAZONE BY DIFFERENT MICELLAR FORMING MATERIALS

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Last updated: 04 Jan 2025

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Abstract

Pyridine-3-Carboxaldhyde thiosemicarbazone (P3CTZ) used in cancer therapy was solubilized by anionic cationic and nonionic surfactant solutions of pH 5,6,7,8 and ionic strength (u) of 0.2 at 47. So sodium dodecyl sulphate (SDS), cetyl trimethyl ammonium bromide (CTAB) and Brij 35 were chosen to represent the last three classes respectively. It was found that SDS has the highest solubilizing efficiency toward P3CTZ followed by Brij 35 and CTAB respectively at all pH values studied. . The stability of P3CTZ was studied in different concentrations of surfactants at pH values of 5,6,7 and 8 and u of 0.2. It was found that the longest t½ observed was in Brij 35 solution of pH 5 at 47° (nearly t½ equal one year). The shortest t½ was found in CTAB solutions. It was found also that the partition coefficient from solubility slightly higher than that obtained from stability measurements. It was concluded that the stability of P3CTZ is greater relatively at higher pH values, than at lower pH values as reported by other workers.

DOI

10.21608/bfsa.1984.89713

Authors

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A.

Last Name

Simonelli

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P.

Affiliation

School of Pharmacy, University of Connecticut, STORRS, CT 06268, U.S.A

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First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

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Last Name

Abdel-Rahman

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

7

Article Issue

2

Related Issue

13482

Issue Date

1984-12-01

Receive Date

1983-11-30

Publish Date

1984-12-31

Page Start

322

Page End

337

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 7_Issue 2_Pages 322-337.pdf

PDF . 528.7kB

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https://bpsa.journals.ekb.eg/article_89713.html

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https://bpsa.journals.ekb.eg/service?article_code=89713

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Original Article

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1,096

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Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

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https://bpsa.journals.ekb.eg/

MainTitle

SOLUBILIZATION AND STABILITY OF PYRIDINE-3-CARBOXALDHYDE THIOSEMICARBAZONE BY DIFFERENT MICELLAR FORMING MATERIALS

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Article

Created At

22 Jan 2023