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70213

A CONTRIBUTION TO THE INTERACTION BETWEEN CHLORAMPHENICOL AND NONIONIC SURFACTANTS

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Last updated: 04 Jan 2025

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Abstract

The interaction between chloramphenicol and some nonionic surfactants has been investigated using both the dynamic and equilibrium dialysis techniques. The surfactants tested were Tweens, Myrjs and Brijs. The permeation of chloramphenicol across a standard cellophane membrane either in absence or presence of increasing concentrations of those surfactants was found to follow first order kinetics. The data revealed that, the presence of nonionic surfactants resulted in a reduction of the corresponding permeation rate constant. The extent of reduction was parallel to the surfactant concentration. The antimicrobial activity of chloramphenicol against B. subtilis (ATTC 663) was examined in presence of these nonionic surfactants. The data revealed that the presence of those surfactants has insignificantly affected the antimicrobial activity of chloramphenicol especially when they were used in concentrations above their respective CMC values.

DOI

10.21608/bfsa.1992.70213

Authors

First Name

S.

Last Name

Ismail

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-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut Egypt

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Orcid

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First Name

F.

Last Name

Habib

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut Egypt

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Orcid

-

First Name

S.

Last Name

Elshanawany

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut Egypt

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-

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-

Orcid

-

First Name

E.

Last Name

Fouad

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut Egypt

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-

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Volume

15

Article Issue

1

Related Issue

10665

Issue Date

1992-12-01

Receive Date

1991-05-12

Publish Date

1992-12-31

Page Start

27

Page End

36

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 15_Issue 1_Pages 27-36.pdf

PDF . 388.8kB

Link

https://bpsa.journals.ekb.eg/article_70213.html

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https://bpsa.journals.ekb.eg/service?article_code=70213

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Original Article

Type Code

1,096

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Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

A CONTRIBUTION TO THE INTERACTION BETWEEN CHLORAMPHENICOL AND NONIONIC SURFACTANTS

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Article

Created At

22 Jan 2023