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70204

THE COMBINED INCLUSION COMPLEXATION OF ACETONE AND FLUNITRAZEPAM WITH DIMETHYL -CYCLODEXTRIN

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Last updated: 25 Dec 2024

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Abstract

Upon recrystallization from acetone, dimethyl  b-cyclodextrin (DM-b -CyD) has shown physicochemical properties changes which were investigated by X-ray diffractometry, differential scanning calorimetry (DSC) and infrared (lR) spectroscopy. X-Ray diffraction analysis showed new crystalline diffraction pattern different from that of intact DM-b-CyD. An endothermic peak was recorded on the DSC thermogram of the recrystallized sample which was attributed to the release of acetone molecules included into DM-b-CyD cavities. Furthermore, the IR spectra of the recrystallized sample showed carbonyl stretching band at 1725 cm-1, although DM-b -CyD has no carbonyl group, which proved the presence of included acetone molecules into DM-b -CyD cavities. The molar ratio of the included acetone molecules into DM-b -CyD molecules was determined by thermogravimetric analysis (TGA) and was found to be 0.73. In addition, when flunitrazepam and DM-b -CyD were recrystallized  from acetone, it was found that flunitrazepam forms crystalline inclusion complex with DM-b -CyD in 1:3 molar ratio showing the same X-ray diffraction pattern of recrystallized DM-b -CyD alone from acetone. This means that the inclusion of acetone molecules into DM-b -CyD took place in addition to the formation of inclusion complex of flunitrazepam with DM-b -CyD.

DOI

10.21608/bfsa.1993.70204

Authors

First Name

Mahrous

Last Name

Ahmed

MiddleName

Osman

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

16

Article Issue

2

Related Issue

10642

Issue Date

1993-12-01

Receive Date

1993-07-19

Publish Date

1993-12-31

Page Start

169

Page End

174

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 16_Issue 2_Pages 169-174.pdf

PDF . 307.0kB

Link

https://bpsa.journals.ekb.eg/article_70204.html

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https://bpsa.journals.ekb.eg/service?article_code=70204

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

THE COMBINED INCLUSION COMPLEXATION OF ACETONE AND FLUNITRAZEPAM WITH DIMETHYL -CYCLODEXTRIN

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Article

Created At

22 Jan 2023