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69786

DRUG RELEASE FROM PLURONIC GELS

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Last updated: 25 Dec 2024

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Abstract

The release rate of progesterone, dexamethasone, ethinylestradiol and a-methyldopa(MD) was determined in aqueous gels of pluronic surfactants (F-65, F-127, F-123) and the effects of concentration and temperature were investigated. The release of drugs from pluronic F-127 could be described by the diffusional model and the rate-controlling stage in the release process is diffusion of the dispersed drug through the matrix continuum. The release-rate decreased as the concentration of pluronic F-127 increased for both dexamethasone and progesterone; and increased as the molecular weight of the pluronic type increased (F-65 < F-123 < F-127) for ethinylestradiol. While, the release rate of a-methyldopa(MD) dexamethasone and ethinylestradiol decreased as increasing concentration of the drug and increasing the temperature, we found that increasing progesterone concentration and temperature;increased the release rate.

DOI

10.21608/bfsa.1994.69786

Authors

First Name

Salwa

Last Name

Safwat

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

17

Article Issue

1

Related Issue

10608

Issue Date

1994-07-01

Receive Date

1993-11-30

Publish Date

1994-07-31

Page Start

41

Page End

48

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 17_Issue 1_Pages 41-48.pdf

PDF . 415.5kB

Link

https://bpsa.journals.ekb.eg/article_69786.html

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https://bpsa.journals.ekb.eg/service?article_code=69786

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DRUG RELEASE FROM PLURONIC GELS

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Article

Created At

22 Jan 2023