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69785

DESIGN AND SYNTHESIS OF' SOME NEW 1H-1,2,4-TRIAZOLES OF POTENTIAL ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES

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Last updated: 25 Dec 2024

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Abstract

The synthesized 1H-1,2,4-triazoles (7a-c, 8a-c and 9a-c), a novel class of heterocyclic compounds of potential anti-inflammatory and analgesic activities, are of interest, since they present some differences compared to the classical non-steroidal anti-inflammatory agents. The anti-inflammatory activity of all derivatives was studied in albino rats using trypan-blue and kaolin-induced edema methods. The compounds were also tested in albino mice for their analgesic activity using the hot plate and p-benzoquinone-induced writhing methods. A correlation between the structures, pharmacological actions and the calculated partition coefficients of the products was studied.

DOI

10.21608/bfsa.1994.69785

Authors

First Name

Hoda

Last Name

Hassan

MiddleName

Y.

Affiliation

Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt

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Orcid

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First Name

Abdel-Nasser

Last Name

El-Shorbagi

MiddleName

A.

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt

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Orcid

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First Name

Nawal

Last Name

El-Koussi

MiddleName

A.

Affiliation

Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt

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City

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Orcid

-

First Name

Ahmed

Last Name

Abdel-Zaher

MiddleName

O.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt

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City

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Orcid

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Volume

17

Article Issue

1

Related Issue

10608

Issue Date

1994-07-01

Receive Date

1993-10-03

Publish Date

1994-07-31

Page Start

27

Page End

39

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 17_Issue 1_Pages 27-39.pdf

PDF . 649.5kB

Link

https://bpsa.journals.ekb.eg/article_69785.html

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https://bpsa.journals.ekb.eg/service?article_code=69785

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DESIGN AND SYNTHESIS OF' SOME NEW 1H-1,2,4-TRIAZOLES OF POTENTIAL ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES

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Article

Created At

22 Jan 2023