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68744

SPECTROPHOTOMETRIC DETERMINATION OF SOME CEPHALOSPORINS USING 2,2'-DIPHENYL-1-PICRYLHYDRAZYL

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Last updated: 25 Dec 2024

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Abstract

A spectrophotometric method was developed for the determination of some cephalosporins using 2,2'-diphenyl-1-picrylhydrazyl (DPPH). The latter employed to abstract a hydrogen atom from the drug thereby promoting a process of radical coupling. This results in a reduction of the violet color (520 nm) of DPPH with the formation of the yellow colored 2,2'-diphenyl-1-picrylhydrazine (DPPH). This fading in color of DPPH reagent depends on the concentration of the drug being determined. Beer's law was obeyed in the ranges of; 5-30, 5-25 and 10-30 µg/ml for cephalexin, cefadroxil and cephradine respectively. The validity of the method was tested by carrying out standard addition procedure analyzing the studied drugs in pure form as well as in their pharmaceutical preparations without interference from common additives. The percentage recovery ranged from (97.98-101.21) ±1.15-0.98.

DOI

10.21608/bfsa.1997.68744

Authors

First Name

Hosny

Last Name

Elsherief

MiddleName

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Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

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Volume

20

Article Issue

1

Related Issue

10407

Issue Date

1997-06-01

Receive Date

1996-10-28

Publish Date

1997-06-30

Page Start

87

Page End

93

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 20_Issue 1_Pages 87-93.pdf

PDF . 379.3kB

Link

https://bpsa.journals.ekb.eg/article_68744.html

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https://bpsa.journals.ekb.eg/service?article_code=68744

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SPECTROPHOTOMETRIC DETERMINATION OF SOME CEPHALOSPORINS USING 2,2'-DIPHENYL-1-PICRYLHYDRAZYL

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Article

Created At

22 Jan 2023