Panax ginseng is among the herbal agents traditionally utilized for thousands of years. It is used commonly as dried roots with possible multifaceted medical characteristics, including anti-inflammatory, anti-neoplastic, tonic, antiviral,  antifungal, and antioxidant, besides its potential actions in healing and restoration. Although many studies discussed the action of one of the components of Panax ginseng, several types of this herb include Panax quinquefolius in America, Pan Ginseng in Korea, and Panax notoginseng in China. This study aims to review the articles that focus on the potential roles of ginseng in general, highlighting the effect of ginseng on several rats' organs. A brief review of the articles discussed the role of ginseng as an anti-inflammatory, anti-neoplastic, tonic, antiviral, antifungal, and antioxidant agent. Several works concluded the multifaceted actions of ginseng at both clinical and animal levels. The products which are obtained from the natural origins (as ginseng)are gained major concerns as pharmacological agents as they are potentially helpful in treating several disorders by their several cytoprotective roles in oxidative stress, inflammation infection(viral and bacterial), malignancy, diabetes mellitus, problems of sexuality beside the disorders of central nervous and cardiovascular systems as these herbs have little toxicity. There is a need to develop new components of ginseng.