Background: Medical Device-Related Pressure injury are skin breakdowns related to certain medical devices. Aim:  Evaluate the effect of implementing educational program about preventive nursing measures of medical devices related pressure injuries on nurses' performance and patients' clinical outcome. Design: Quasi-experimental research design. Setting: Surgical Intensive Care Unit of Emergency hospital at Tanta University. Subjects: two samples included all nurses (70 nurses) and Purposive sampling of 60 adult critically ill patients who admitted to the previous mention settings and divided into two groups 30 in each. Tools: Three tools were used for data collection. Tool (I) demographic characteristics of nurses and nurses 'knowledge about MDRPI. Tool (II) Nurses' observational checklist. Tool (III): Patient' clinical outcome Assessment. Results: A highly significant improvement of total mean score of studied nurses' knowledge and practice immediately and post 3 weeks of educational  program implementation compared to pre-program with P= 0.00. Also 30.0% of patients of control group had oral mucositis in lips compared to only 3.3% of study group on 2^nd week of program implementation. Conclusion: Significant improvement of the total means score of nurse's knowledge and practices were observed at immediate phase. However this improvement was reduced by time. Oral mucositis and stages of pressure injury were decreased significantly among intervention group. Recommendation: Encouraging nurses to participate in seminars, conferences and workshops about MDRPI. Replication of study on large sample