Background: Priapism is a painful and protracted penile erection that usually holds up more than three to four hours without stimulus, requiring emergent treatment to avoid tissue damage or/and erectile dysfunction. Nursing care for a patient with priapism focus on assessment of health history, emergent pain control, medications administration and health education. The aim of the study: This study was designed to evaluate the effectiveness of priapism's structured educational module on nurses' knowledge, attitude, & beliefs, and patient's profile. Subjects and Methods: Design: A quasi-experimental design was used (pretest, posttest, and follow-up) in this study. Subjects: Two subjects were recruited; the first was 32 convenient nurses' samples, and the second was 28 purposive patients' samples. Settings: This study was conducted at Andrology and Urology department in Suez Canal University hospitals. Tools: Utilizing three tools to collect data: Nurses' knowledge self-administered questionnaire, Nurses' attitude, & beliefs interviewing questionnaire, and patient's profile questionnaire. Results: Nurses' knowledge, attitude, and beliefs were significantly improved at the post and follow-up of educational module implementation compared to pre-phase. Moreover, more than three quarters (75%) of the studied patients were married, as well as there was a significant improvement in patient's profile among the studied patients cared for by the studied nurses at the post and follow-up phase with P value=0.01. Conclusion: The result's study revealed that improvement of nurses' knowledge, attitude, and beliefs and the patient's profile with the studied patients at post the educational module phase. Recommendation: A primordial endorsed nursing guideline about priapism in the orientation program for nurses to knowledge, attitude, and beliefs. Conducting periodic in- services education in a specialized unit regarding the care of priapism is essential plus patients' educational guidelines to improve their profile