Background: Changes in healthcare organizations are ongoing, but their implementation is extremely difficult, so healthcare worker should work together. Supportive professional practice environment is significantly associated with quality of care, stimulating and managing organizational change. Aim: to assess the relation between intensive care units nurses' readiness for change and work environment characteristics at El – Menshawy General Hospital. Subjects and Method: Study design: A descriptive correlational study design was used. Setting: The study was conducted in all Intensive Care Units (ICUs) of El Menshawy General Hospital. Subjects: It consisted of all (n=164) nurses working in ICUs. Tools: Two tools were used, Readiness for Change Questionnaire and Nursing Work Environment Characteristics Questionnaire. Results: The results showed that 66.6% of the ICU nurses' had weak levels of overall readiness for change. 58.5% of the ICU nurses' perceived fair level of nursing work environment. Conclusion: There was a statistically significant positive correlation between overall ICU nurses' readiness for change and their work environment. Recommendations: Informing nurses about policies and practices that decrease the potential negative impact of the proposed change. Conducting training program that support nurses to be adapted with change. Creating an environment which encourages nurses to participate in decision making.