Background and Aim: Endometriosis affects 5 to 15% of women in their reproductive years. It causes a wide range of social, psychological, and emotional issues. The study aimed to evaluate effectiveness of adoption of positive coping strategies on women's knowledge and practices related to endometriosis. Subjects and Methods: This study used quasi-experimental research design. The research was carried out in Egypt at the endoscopy section of Zagazig University Hospital and Al Ahrar Hospital. A purposive sample of 150 women with endometriosis was included four tools were used to collected the necessary data. (I) A systematic interviewing questionnaire (II) laparoscopic (III) the Numeric Pain Rating Scale, endometriosis rating by the American Society of Reproductive Medicine and (IV) women's knowledge and practice questioner. Results: The study findings revealed that adopting the identified coping strategies women's knowledge and practice with, pain related to endometriosis (P<0.000). Conclusion: Adoption of Positive coping strategies had a significant effect on women's knowledge, practices related to endometriosis. Recommendations: This study emphasizes the critical significance of nurse education initiatives and programs in promoting awareness, knowledge, and behaviors and practices related to endometriosis among women.