Background: Oncology nursing services are performed in stressful work environments which affect their work engagement. Head nurses' empowerment and support are confirmed strategies for creating a positive workplace environment which in turn improve oncology nurses work engagement. The study aimed to determine the efficacy of leadership program for head nurses' empowering and supportive role on nurses' work engagement at Tanta Cancer Center (TCC). Research design: A quasi experimental design was utilized to meet the aim of this study. Setting: Study was conducted at TCC affiliated to Ministry of Health. Subjects: All (230) nursing staff include head nurse (n=30) and nurses (n=200) were participated in the study Tools: Three tools were used; (1) Head nurses' empowering and supportive role practice self-report (2) Nursing staff knowledge questionnaire (3) Nurses' work engagement scale. Results: Range (80.9% -76.1%) of nursing staff preprogram had poor knowledge level about empowering and supportive roles of head nurses which highly statistically significantly at (p < 0.001) improved post program to be range (84.8% - 79.1%) have good level of total knowledge. Head nurses range (60% - 50%) had unsatisfactory level of total empowering and supportive role practice preprogram, changed significantly at (p < 0.01) post program to be range (83.3% - 73.3%) had satisfactory practice level. Preprogram nurses range (65.5% - 64%) showed low engagement level for vigor, dedication and absorption respectively changed post program to be 66%, 63.5%,and 67% respectively had high level of work engagement. Conclusion: The designed and implemented leadership program significantly improves head nurses' empowering and supportive role and oncology nurses' work environment. Recommendation: Head nurses periodical attend leadership program to update their empowering and supportive knowledge and practice.