Background: Assessment of Bio-psychosocial needs of patient pre and post open heart surgery are very important aspect of patient centered care. Aim: was to assess patients' needs pre and post Open Heart Surgery. Design: -A descriptive exploratory design was utilized in this study. Settings: This study was conducted at Cardio-Thoracic Intensive Care Unit of Educational Tanta University Hospital. Subjects: A convenience sample of (100) open heart surgery patients that had been admitted to Cardio-Thoracic Intensive Care unit and meeting the inclusion criteria. Tools of the study: Two tools was used in this study for data collection: Tool I:A structured Interview Schedule Tool II:Bio psychosocial Needs Interview Questionnaire which included three parts; part (1): Physical Needs for Patients undergoing Open Heart Surgery, part(2): Psychological Assessment for Patients with Open Heart Surgery and part (3) Social Dysfunction Rating Scale for Patients with Open Heart Surgery. Results: There was highly significant positive correlation between total Social Dysfunction of the studied patients and their total score of pain score and total score of psychological needs at (P= < 0.01). In addition, there were significant positive correlation between total score of pain score of the studied patients and their total score of psychological needs and total score of Social Dysfunction at (P= < 0.01). Conclusion: The study concluded that, three-quarters of the studied patient had unsatisfactory level of total knowledge about heart surgeries. Also, there was a marked increase in total patients' dependency in Activities of Daily Living level at post heart surgery. Recommendations: Routine pre and postoperative assessment of patients who are undergoing open heart surgery is recommended to identify the different patient's biopsychosocial needs and consequently any risk factor and reduced the post-operative complications.