Background: In-hospital falls are a significant clinical, legal, and regulatory problem, moreover, is considered one of the nursing-sensitive quality indicators and essential goal of international patient safety goals IPSG. In hospital falls well-thought-out to be any unintentional positional change that results in the person coming to rest on the ground, floor, or other lower surface. Falls are the most frequently reported incidents among hospitalized patients. It is considered a challenge for healthcare workers because information on effective fall reduction is lacking. The study aimed to determine the effect of implementing fall prevention strategies on nurses' performance at Neurological Intensive Care Units. Subjects and Method: Design: A quasi-experimental design was utilized in this study. Setting: The study was conducted at Neurological Intensive Care Units in Neurological Medical Center, in Tanta Main University Hospital. Subjects: All nurses (50) nurse from Tanta University Neurological Intensive Care Units. Tools: Three tools were used to collect data: Tool I: Nurses' knowledge and socio-demographic characteristics Tool II: Nurses compliance fall prevention tool: (Rounding tool) Tool III: Nurses' performance for prevention of patient fall checklist. Results: The main results of this study revealed that there was a significant improvement in the mean scores of the total level of knowledge and practice immediately and one-month post-program implementation in a studied group at P < 0.05. Conclusion: Conclusion: The study findings revealed that nurses' performance of intervention for patient fall prevention had improved after the application of the educational program. Recommendation: It was recommended that an In-service training program should be conducted continuously for nurses regarding fall prevention strategies and essential presence of nurse's instructor to distribute guideline booklet with knowledge and practices about patient fall prevention.