Background: COVID-19 creates a negative impact across healthcare sectors and performance appraisal is one of the most areas in nursing management which is significantly affected. Aim of the study: This study aimed to explore effect of educational program about nurse managers' performance appraisal during COVID19 on staff nurses, satisfaction and motivation. Subjects and method: Quasi experimental research design was utilized. The study was conducted in all departments at cardiology center at El Mehallah El Kobra city. All (n =30) nurse managers and all (n=183) staff nurses worked in the same setting are involved in the study. Four tools were used to gather the data: nurse managers, role in managing performance appraisal during COVID 19 self- reporting questionnaire, nurse managers, performance appraisal knowledge questionnaire, staff nurses' satisfaction with performance appraisal scale and staff nurses' job motivation scale. Results: All nurse managers had low level in their role in managing performance appraisal during COVID- 19 and in total level of knowledge preprogram compared to the majority and nearly two-thirds had high level post program in role and knowledge, respectively. Statistically significant improvement was found in levels of staff nurses' satisfaction with performance appraisal and motivation post program implementation. Conclusion: Educational program for nurse managers on performance appraisal during COVID 19 plays a vital role in increasing staff nurses' satisfaction and motivation. Recommendation: Prime importance to modify performance appraisal forms to adapt to any changing that occurs in environment and receives continuous feedback from staff nurses about their satisfaction with present performance appraisal system.