Background: Pandemic outbreak of highly contagious coronavirus (COVID-19) became a major threat to our physical and mental health due to the rapid spreading and related countermeasures particularly lockdowns. Population commitment to preventive measures of COVID-19 and political decisions taken depending on their sufficient knowledge and positive attitude about this disease. Aim: This study was conducted to assess public knowledge, attitude and practice regarding COVID-19 pandemic in Al Gharbia Governorate, Egypt. Design and Setting: Cross-sectional study was used among the general population at Al Gharbia Governorate Egypt, from April 18 until May 18, 2020. Sample: 526 participants whom complete the online survey at Al Gharbia Governorate Egypt. Tools: The online survey questionnaire was developed by the researchers. It consisted of four parts; socio-demographic data, a COVID-19 knowledge, attitude and reported practices questionnaire. Results: This study was revealed that the majority (89.1%) of the studied sample had good knowledge. TV was the commonest source (77%) followed by social media (67.10%) for this knowledge. While, half (50%) of them had reported poor practices regarding COVID-19. Conclusion and Recommendation: Our study showed that in spite of the respondents have exhibited good knowledge, positive attitude but they reported poor practices regarding covid-19 during the pandemic. So, we recommended that a health educational program should directed to high risk groups it will be more effective in prevention and control of COVID- 19 and all public should maintain commitment of precautionary measures.