Physical restraint is any manual method or mechanical device attached to the patient's body that restricts freedom of movement and cannot be easily removed. Despite extensive literature on the potential complications of using physical restraint, it is still considered as a permanent and effective intervention in the management of unpleasant behaviors. This study aimed to assess patients' and nurses' opinion about uses of physical restraint on psychiatric patients in Mental Health Hospital. Study was conducted in Tanta Mental Health Hospital which is affiliated to Ministry of Health. The study subjects include 49 psychiatric patient and all nurses working in Tanta Mental Health Hospital (80 nurses). Two tools were developed by the researcher to collect the necessary data. Tool (1) was Patient Structured Interview questionnaire, and Tool (2) was nurses structured Interview questionnaire. The main results revealed that a round one third of studied patients had negative opinions about use of physical restraint, and nearly half of them were average. In another hand more than half of studied nurses had positive opinion and nearly to one third were average regarding to using of physical restraints, so it was recommended that nurses should be involved in educational program about; therapeutic use of self and effective communication skills to improve their interaction with patient and encourage them to express gradually about their strong feeling, and educated about aggressive behaviors, it's dynamic and predisposing factors, and how applied physical restraints effectively with patients and debriefing following these procedure to minimize a negative effects on patients