Two local strians of chickens Gmmizah (G) and Doidd-4 (D.), at age of 48 weeks were used in this study. Ninety- six individuals of each strain (90 hens + 6 cods) were distributed randomly into 6 groups for each strain to present three levels of aflatoxin Bh (AFB,) 0.0, 2 and 5 ppm. Within each of AFElt grows, two levels of mycodote as antitoxin 0.0 and 0.01% were added. Bads of both strains were exposed to toxin and toxin plus mycodote for three weeks (treatment period). Thereafter, they were fed for 4 weeks on free aflatoxin and mycodote diets (recovery period). Results of overall means were determined and summarized as follows: 1. There was slight increase in the concentration of ALT(Alanirie amill0Irellsferase), alkaline phosphates (ALP) and creatinine enzymes for those fed contaminated dets. Plasma total protein, albumin, and globulin concentration showed slight decrease during treatment period. 2-The treated groups fed on AFBI without mycodote had significantly higher aflatoxin residue in egg yolk than in albumen. Slight effect lasted blithe end of the recovery period for birds. 3-The liver contained the highest levels of aflatoxin residues compared to the spleen, heart, breast, gizzard and thigh tissues. 4-The two local breeds showed different and promoting effect in effecting aflatmdcosis. However, administration of mycodote ameliorated the negative effect of of atoodn B1 in the diet. Also, the recovery period for four weeks was not sufficient to bring the birds to normal production activity.