In the first twenty-four hours after a severe burn, it is difficult for burn care experts to resuscitate a patient with a large acute burn. Any possible post-burn alterations should be communicated to the nurse caring for a patient with burn injuries. The aim: Determine the effect of fluid resuscitation educational intervention on nurse's knowledge, practice and fluid creep related manifestations for patients with burn. Design: a quasi-experimental research design. Setting: Burn unit at Tanta University hospital. Subjects: a purposive sample of 27 nurses and 40 patients (control & study). Tools: Four tools were used; Nurses; knowledge questionnaire, Nurses' practice observational checklist, Burned patient's assessment and Fluid creep related manifestations assessment. Results: Significant improvement of mean scores of nurses' knowledge and practice immediately post intervention (p = < 0.001). There was a high significant difference between the study and control group in relation to the overall fluid creep manifestations (p = < 0.001), also there was a negative significant correlation between the nurses' overall knowledge, practice and patients' overall fluid creep related manifestations with p equal < 0.05. Conclusion: Nurses' knowledge and practice mean scores had increased significantly post implementation of fluid resuscitation educational intervention for patients with burn compared to pre- implementation of the educational intervention. This improvement had a significant positive effect to decrease fluid creep related manifestations among patients with burn. Recommendation the study addressed the importance of continuous assessment of the nurses' educational needs to design and implement periodic educational intervention and workshops accordingly.