Background: Hyperprolactinaemia is the presence of abnormally high levels of prolactin in the blood. Normal levels are [20-25 ng/mL or μg/L] for women, Hyperprolactinaemia can also be a part of normal body changes during pregnancy and breastfeeding. Aim: To evaluate the impact of the nurse's role on the management of hyperprolactinemia, Sampling: convenient sample included 100 women started from April 2019 to March 2020. Research design: A Prospective study ( randomized controlled trial) was utilizied in this study. Setting: The study was conducted at the laboratory (Woman's Health Hospital lab, Assiut University). Results: It is illustrated that there is statistical significant difference between the study and the control groups regarding prolactin value, as the majority of studied women have a normal value in the study and abnormal value in the control groups p-value 0.001. Conclusion: The nurse carry a vital role for hyperprolactinemia through health education including (feeding habits, Life style and sexual behaviors). in assessing and managing hyperprolactinemia. and thus increase the quality of life. Recommendations: support the nurses's role in assessing and managing hyperprolactinemia through providing a counseling that needed to women