Tophi gout is a noticeable, and painful inflammatory arthritis that is associated with a lump of monosodium urate deposition in the joint or/and other body parts. Nursing care is a cornerstone of the management process that plays a vital role in its prevention and management. Purpose: This study aimed to evaluate the impact of designed nursing guidelines about tophi gout's lifestyle modification on patients' outcomes. Sample: A purposive sample (136) of patients were recruited. Design: A quasi-experimental research design (one group pre-posttest) was used at Rheumatology and Rehabilitation department. Tools: Utilizing two tools; (1) Daily lifestyle health assessment is a structured interviewing questionnaire to assess demographic characteristics, health history, and lifestyle habits. (2) Structured interviewing patients' outcomes questionnaire to assess the patients' outcomes. Results: More than half the studied patients (55.7%) were male. Implementation of designed nursing guidelines about tophi gout had significant improvement of patients' healthy lifestyles and outcomes at the study phases. There was significant correlation between the total lifestyle modifications and pain perception score at the study phases with p≤0.05. Conclusions: Productively designed nursing guidelines about tophi gout's lifestyle modification enhanced a healthy lifestyle and patients' outcomes. Recommendations: Endorsement and support patients with designed nursing guidelines about tophi gout to early prevention from its flares.