Background: A cesarean section is associated with increased maternal risks, such as puerperal sepsis, hemorrhage, thromboembolism, despite the gross increase in cesarean section rate; there is still high perinatal mortality. Aim & design: Quasi-experimental study design was conducted aiming to evaluate the effectiveness of the designed postoperative nursing management protocol on nurses' performance regarding care of women undergoing cesarean section. Sample: 40 nurses were chosen as a convenience sample in this study, which was carried out at Postnatal Inpatient tpemtDapeD at Ain Shams University Maternity Hospital. Tools: the study utilizes three tools: A structured interview questionnaire, an observational checklist, and nurses' satisfaction questionnaire, in addition to developed supportive material (post-operative nursing management protocol). Results: The results showed statistically significant improvements in nurses' performance (knowledge and practice) at teDptepeDtte -etsD compared with Dhp pre-intervention level (p < 0.001). In addition to 90% of nurses were satisfied with nursing management protocol. Conclusion: Findings of this study conclude that the post-operative nursing management protocol was effective in improving nurses' performance regarding care of women undergoing cesarean section and most of them were satisfied with it. Recommendations: applying continuous refreshment courses and follows up programs for nurses regarding post-operative care of cesarean section women.