Abstract Coronary Angiography has become a main diagnostic procedure for diagnosis of Coronary Artery Disease (CAD). Aim: this study was carried out1- to investigate the impact of knowledge aboutearly ambulationon patients' satisfaction among post coronary angiography2-early ambulation after 2 hours versus 6 hours.Design: a quasiexperimental design. Setting: in catheterization and coronary care units.Subjects: A convenience sample of all adult educable and mentally competent male and female patients aged from (18-60 years old) who had undergone a nonemergency coronary angiography (CA) through femoral artery during a period from July 2010 to June2011 were eligible for inclusion in the sample.Tools: four tools were utilized to collect data pertinent to the study, tool I assessment of patients after femoral sheath removal and angiography related data tool II: pre/post femoral coronary angiography knowledge sheet toolIIIpre/post femoral coronary angiography observation check list.toolIV satisfaction assessment sheet. Methods: pretest knowledge sheet filled out by the patient and observation checklist sheet was checked by the researcher for both groups ,the teaching protocol has been implemented for patient in terms of session ,each session ranged from 6-10 patients for theoretical and practical contents ,then immediately post knowledge sheet test filled out by the patient and observation checklist sheet was checked by the researcher for both groups Results: Finding of the present study revealed that significant improvement of all parameters with values of less than p=0.001 in response to give information among the two groups CA. Conclusion: educating patients before diagnostic cardiac catheterization can effectively improve level of knowledge and satisfaction.