Background: Nurses may vary in communication skills as well as in their desire to really understand the patient, peers and others this could compromise the issue of advocacy. So it is important to improve nurses' communication competence to effective nurses' self-advocacy. Study aim to evaluate the effect of designed program of communication competence on nurses' self-advocacy. Research design: quasi experimental research design used. Subjects: No. = (42) staff nurses. Setting; Sohag University Hospital Tool; consists of three parts; 1) personal characteristics; 2) Communication Competence Scale; and 3) Self-Advocacy Scale. Results: mean score of total communication competencies at pre intervention (78.31±16.74), post (112.67±10.61), and follow up (106.17±9.7). Mean score of total self-advocacy at pre intervention (19.17±3.999), post (30.26±3.85), and follow up (25.81±3.4498). Conclusion; there were positive correlation between communication competence and self-advocacy with highly statistical significant difference. Recommendations: implementation of communication training program in nursing education, assess communication competency among nurses periodically, and undergraduate nursing programs should contain communication competency course.