Abstract: Background: Professional practice model is a reasonable and viable alternative to the traditional nursing practice models used in many hospitals. Aim: assess the effect of professional practical model on Nurse Manager's work satisfaction. Study design: A descriptive correlational design. Setting: at different Hospitals at Assiut University. Subject: Convenient sample of Nurse Manager's work at Assiut University Hospitals No. = (168) at all units. Methods: The data were collected using: Self-administered questionnaire including: personal data sheet, professional practical model questionnaire & work satisfaction scale nurse (WSSN). Results: The highest mean score of items of professional practical model in El Rajhe hospital in the study subject Professional development, Shared governance, Primary care team, Quality outcomes, Transformational leadership and Stewardship. While the highest mean score of items Teamwork in Al Orman Hospital, followed by in El Rajhe hospital) Conclusion: and finally in main hospital, this resulted statistically significance differences among hospitals in the study in items Stewardship, Teamwork, Quality outcomes and Primary care team., There was a highly positive correlation between professional practical model and work satisfaction items. Recommendation: Encourage the nurse manager to Participate in workshop about Professional practical model to increase their commitment toward goal achievement.