Background: Maternal morbidity and mortality remain unacceptably high in developing countries. Behind every maternal death, a lot of women suffered from acute and chronic obstetric complications. Women who survive severe acute maternal morbidities/near miss have many characteristics in common with maternal death events particularly on risk factors. The aim: Was to assess nurse's knowledge about maternal near-miss cases at Woman's Health Hospital, Assiut University. Subjects and methods: This study was conducted at Woman's Health Hospital, Assiut University from June to November 2019, A descriptive cross-sectional study and a convenience sample of 146 nurses (126 diploma nurses and 20 baccalaureate nurse) was used. A self-administered structured questionnaire for nurses regarding maternal near-miss was used to collect the data. Results: The majority of nurses showed an inadequate level of knowledge about maternal near-miss cases in most of the items like (definition & causes of maternal near-miss, symptoms & management of shocking cases, their knowledge about postpartum hemorrhage, preeclampsia, pulmonary embolism as principal causes of maternal near miss) Conclusion: It was concluded that the knowledge of nurses on maternal near-miss cases was inadequate. Recommendations: Results suggests an urgent need for education and awareness programs for improvement in nurse's knowledge regarding maternal near-miss cases.