Abstract Nurses play an important role in clinical stability, adequate hydration, patient comfort and psychological readiness to undergo percutaneous coronary intervention (PCI) procedure. This study aimed to assess nurses' knowledge and practice for patients undergoing PCI. Subjects and method: A descriptive research design was utilized. A convenience sample of (72) nurses who were working in the cardiology department at Assiut University-Orman Heart Hospital were included in this study. Setting: The study was carried out in the cardiology department at Assiut University-Orman Heart Hospital. Tools: Self-administered questionnaire sheet for nurses was utilized including the following parts; Part 1: '' Nurses' Personal demographic data'', Part 2: '' Nurses' knowledge regarding PCI'', Part 3: '' Nurses' practice observation checklist sheet''. Results: The majority of the study sample had unsatisfactory knowledge regarding PCI and poor practice in some items of care. Conclusion: The study findings revealed that the majority of the study sample had unsatisfactory knowledge and poor practice in some items of care for patients undergoing PCI. Recommendation: The study recommended that a designed nursing care guidelines for patients undergoing PCI must be developed.