Background: Uterine fibroids place a large economic burden both on the women who suffer from them, and on the health systems and societies in which they live. Symptoms may lead to significant loss of working time, and other consequences such as spontaneous abortions, pre-term delivery and Caesarean sections. Aim: The present study aimed to assess the effect of uterine fibroid on their women's life and to evaluate the effect of nursing program for women's undergoing hysterectomy. Design: Descriptive and a quasi-experimental design were utilized to conduct this study. Setting: the study was conducted at Gynecological outpatient clinic and department at Zagazig University Hospital. Sample: purposive sample 285 females with UF were recruited for estimating average health related quality of life (HRQOL) and 50 females undergoing hysterectomy was choose for the program. Tools: four tools were used in the present study; Tool I: a structured interview questionnaire, Tool II: scale of HRQOL, Tool III: patient record and nursing management checklist and Tool IV: follows up scale of HRQOL after 3 month of the program. Results: the majority of the sample was ≥ 40 years, (81.8%) of studied woman had severity of symptoms, woman had negative impact on HRQOL concern, control , energy, activities, self-conscious and sexual function ( 90.2%,86.7%,84.2%,83.2%, 81.1% and 63.5%)(severe score ≥ 75%) Conclusion: Severity of symptoms had very great deal in almost subjects in the present study. Fibroids impact negatively on women's health and quality of life. After the program intervention, women's health related quality of life had been improved in the study group except impaired in sexual function. Recommendation: Preoperative assessment and counseling of patients undergoing hysterectomy concerning alleviation of fear and clearing up misconception are essential to reduce postoperative pain, prevent complication and improve patient's quality of life.