A temporary pacemaker is an electronic device which provides electrical stimuli to the heart, when the sinoatrial node fails to conduct regularly to the ventricles. Aim of the study: This study aimed to assess nurse`s knowledge and practices regarding temporary pacemaker patient`s care. Research design: A descriptive research design was utilized in the study. Sitting: This study was conducted in Coronary Care Unit at Assuit University Hospital. Subject and Method: The study was carried out on a convenience 40 nurses who are working in coronary care unit. Tools: Tool 1: Nurses` knowledge assessment tool regarding temporary pacing. Tool 2: Observational checklist regarding care for patient with temporary pacemaker. Results: The results showed that (77.5%) of nurses had unsatisfactory level of knowledge regarding care for patient with temporary pacemaker and (92.5%) of nurses had unsatisfactory level of practices regarding care for patient with temporary pacemaker. Conclusion: Nurses showed inadequacy of their knowledge and practices regarding temporary pacemaker patient's care. Recommendation: The study recommends that there is a need for an education program regarding care for patients with temporary pacemaker.