Sedation can help alleviate pain of intrusion allows patients to tolerate painful/distressing procedures optimize mechanical ventilation used to decrease O2 consumption, decrease ICP in neurosurgical patient,and facilitate cooling Control agitation. Reduce anxiety to alleviate pain, for amnesia during neuromuscular blocked. Aim of the present study was to evaluate the effect of implementing nursing guideline on critically patients' outcomes regarding sedation in ICU at Assiut University Hospitals. Design: Quesi experimental design was used to conduct the aim of this study. Subjects: A purposive sample of 60 adult's critically ill patients from both Sexes admitted in the general intensive care unit at Assiut University hospital Tools: Tool I: Patient assessment sheet, Tool II: Sedative assessment scales Method: the researcher used the study toolsand implement nursing guideline for study group. Results: finding of the present study revealed that there was a signifficant statistical diffrences between both study and control groups in relation to sedative complication tracheostomy, long ICU stay, and mortality (p < 0.05) Conclusion: implementation of nursing guidline about sedation was significantly effective in improve outcomes of critically se