Background: Unstable angina is a type of ACS. The aim of the study: Assess nurses' knowledge and practice
regarding patients with unstable angina, Design nursing care protocol for nurses working within CCU, and evaluate the effect of the nursing protocol on nurse's knowledge and practice. Hypotheses: (1) the post mean knowledge scores of nurses will be higher than their pre mean knowledge scores. (2) The post mean practice score of nurses will be higher than their pre mean practice scores. (3) A positive relationship between knowledge and practice score. Research design: Quasi-experimental a sample of (35) nurse. A study was conducted in CCU at Aswan University Hospital. Tools: Three tools a) structured interview sheet. b) Observation checklist sheet. c) Construction of designed nursing protocol. Results: The hypotheses were supported as improvement in the mean knowledge & practice scores after implementing of the nursing protocol. The hypothesis was supported by a positive relationship between nurse's knowledge and practice scores after application