Hypoalbuminemia is a common health problem among liver transplant patients. Moreover, it is documented that 20% of liver transplant patients have hypoalbuminemia at admission. Aim of study: To evaluate the effect of teaching program on nurses' performance about hypoalbuminemia after liver transplantation. Research design: A quasi experimental (pre/post test). Subject and Methods of this study was consisted of 30 nurses' care for hypoalbuminemic patients after liver transplantation. Two Tools were used for data collection. Tool I pre/post nurses' knowledge assessment questionnaire. Tool II pre/post observational checklist. Results: The study explained that the majority of nurses had poor knowledge and practice related to hypoalbuminemia after liver transplantation before teaching program, which has been improved after teaching program significantly (P=0.000), a positive correlation was found between knowledge and practice scores of the study subjects significantly (P=0.000). In Conclusion, teaching is important to clarify, remind, and master nurses' knowledge and practice would have a positive impact upon their knowledge and practice. The study Recommended that continuous In–service training programs for the purpose of updating the knowledge and practice about hypoalbuminemia after liver transplantation for nurses