Human resources are an absolutely necessary input for organizational effectiveness, particularly in the hotel industry. This study aimed to investigate the relationship between perception of organizational politics (POP) and human resource management practices (HRMPs) among hotel supervisors. The empirical analysis was based on data collected from 15 five star hotels allocated in Sharm El-Sheikh in Egypt. A total of 144 responses were analyzed. The findings revealed a significant negative correlation between supervisors' POP and their perception of HRMPs. Supervisors' perception of organizational politics has a considerable effect on their perception of human resource management practices. This study could help hotel properties to develop strategies that maintain a climate of trust within the organization in order to improve the organizational environment and the quality of work life by making sure that organizational resources are allocated in an equitable or strategically justifiable manner and by making sure that communication channels are streamlined, focusing on employee participation, linking compensation with performance; ensuring just decision-making procedures are in place.