Behçet's disease (BD) is a multisystem inflammatory disease characterized by recurrent orogenital ulcerations, ocular inflammations, and skin lesions. The etiology of the disease is currently unknown but evidences suggested that there is a strong genetic component mediating the chronicity of the disorder. Cytokines seem to have important roles in the pathogenesis of BD. Its production could be affected by genetic polymorphisms. Thus, this study aimed at investigating the associations between BD in Egyptian population and IL-6 (-174) promoter polymorphism. We genotyped IL-6 (-174) position in the promoter region of IL-6 using Mutagenically Separated PCR (MS-PCR) in 61 Egyptian patients with BD and 97 healthy-matched control. No significant association between IL-6 (-174) polymorphism and BD was found. Only two genotypes were seen in the gel GC and GG there was no CC in BD or control. No significant association between IL-6 (-174 G/C) polymorphisms and BD was demonstrated. Moreover, there was no significant difference between G or C allele distribution between BD and controls. Comparing patients with various disease manifestations, we found no significant association with the -174 G/C genotypes. A remarkable increase (even not statistically significant) in the frequency of IL-6 -174 GG (92.6%) in BD patients in active state as compared to BD inactive (73.5%) was found. In conclusion, our data revealed that IL-6 -174 promoter polymorphism does not contribute significantly to BD disease susceptibility or to distinct clinical feature.