67801

Effect of Repetitive Transcranial Magnetic Stimulation with High Frequency Versus low frequency on Motor Symptoms of Parkinson's Disease

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Last updated: 04 Jan 2025

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Abstract

Background: There is evidence that both high and low frequency repetitive transcranial magnetic stimulation (rTMS) may have therapeutic effects on motor performance of Parkinson's disease (PD). Objective: The aim of the study was to conduct direct comparison of the two approaches. Patients and Methods: Sixty PD patients who attended The Neurology Clinic of Kobri El-Koba Military Hospital, Maadi Military Hospital and Al-Hussien University Hospital, Egypt from December 2018 to October 2019. They were randomly classified into three groups. Group I (sham group) received inactive stimulation, Group II received 5 Hz and group III received 1 Hz rTMS with a total of 2000 pulses over primary motor cortex (M1) of each hemisphere for ten days. Effects were assessed with the Unified Parkinson's Disease Rating Scale part III (UPDRS) the day before stimulation, one week after the last session, and one month later. Results: There was a significant improvement in all parts of UPDRS part III after 5 Hz rTMS (group II), and the effect persisted for one month after stimulation. As regard the Stage of disease, according to modified Hoehn and Yahr staging, there was an improvement in group II staging as nine patients improved to stage 2 where balance was regained and three patients in stage 5, as the severest stage, where patients were chair bound or bedridden improved partially to stage 4 and became able to walk unassisted with difficulty. Conclusion: 5 Hz rTMS over M1 is superior to 1 Hz rTMS for motor symptoms of PD, particularly in advanced stages showing motor complication.

DOI

10.21608/amj.2020.67801

Keywords

Repetitive transcranial magnetic stimulation, Parkinson's disease

Authors

First Name

Kamel

Last Name

Mahmoud Hewedi

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Affiliation

Department of Neurology, AL-Azhar Faculty of Medicine, Cairo, Egypt

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First Name

Ahmed

Last Name

Essmat Ali

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Affiliation

Department of Neurology, AL-Azhar Faculty of Medicine, Cairo, Egypt

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Orcid

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First Name

Ahmed

Last Name

Abdelbaset Ahmed

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Affiliation

Department of Neurology, AL-Azhar Faculty of Medicine, Cairo, Egypt

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a7medhamour@outlook.com

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Volume

49

Article Issue

2

Related Issue

10133

Issue Date

2020-04-01

Receive Date

2020-01-08

Publish Date

2020-04-01

Page Start

399

Page End

410

Print ISSN

1110-0400

Link

https://amj.journals.ekb.eg/article_67801.html

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https://amj.journals.ekb.eg/service?article_code=67801

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6

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Original Article

Type Code

941

Publication Type

Journal

Publication Title

Al-Azhar Medical Journal

Publication Link

https://amj.journals.ekb.eg/

MainTitle

Effect of Repetitive Transcranial Magnetic Stimulation with High Frequency Versus low frequency on Motor Symptoms of Parkinson's Disease

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Article

Created At

22 Jan 2023