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211745

Study of Serum Spexin Level in Obese and Non-Obese type 2 Diabetic Patient

Article

Last updated: 04 Jan 2025

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Tags

Clinical Research (Medical)

Abstract

Background: Spexin is a peptide, which is discovered as an important regulatory adipokine in obesity, insulin resistance (IR), and diabetes. Aim: To evaluate serum Spexin levels in type-2 diabetic obese patients in comparison to its levels in non-obese diabetic (NOD) and to assess its relationship to IR and glycemic control. Patients and methods: A total of 20 NOD (group 1), 22obese non-diabetic (OND) (group 2), and 24obese diabetic patients (OD) (group 3), with an average age of 43.8±8.9, 49±8.8, 45.1±11.6 years respectively, and 20 age and sex-matched healthy participants (control group) were included. Height and weight were measured using standard techniques. Glucose levels, triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting insulin (FI), calculation of Homeostasis model assessment insulin resistance (HOMA-IR), and Spexin levels were measured in each patient. Results: The median serum Spexin levels were significantly lower in the OD than in the other groups and lower in the NOD and OND than in the non-obese non-diabetic (NOND)(p <0.001). Spexin level at a cutoff value ≤ 0.70 can significantly discriminate OD from NOND. Spexin levels were negatively correlated with age, body mass index (BMI), LDL-C, TG, FI, and HOMA-IR. Conclusion: Spexin plays an important role in glucose homeostasis and lipid metabolism. The presence of diabetes is associated with lower Spexin levels. Further investigations and additional studies in larger populations are required to understand the exact function of this peptide and to validate the observations in the current study.
 
 

DOI

10.21608/scumj.2022.211745

Keywords

Obesity, diabetes, adipokine, Insulin Resistance

Authors

First Name

Yasmin

Last Name

Mashaal

MiddleName

S

Affiliation

Department of Internal Medicine, Zarka Central Hospital, Egypt,

Email

-

City

-

Orcid

-

First Name

Attaa

Last Name

Bakr

MiddleName

M

Affiliation

Department of Internal Medicine, Endocrinology Unit, Faculty of Medicine, Mansoura University.

Email

-

City

-

Orcid

-

First Name

Azza

Last Name

El-Baiomy

MiddleName

A

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

azzabaiomy263@mans.edu.eg

City

-

Orcid

-

First Name

Naglaa

Last Name

Abbas

MiddleName

E

Affiliation

Department of Internal Medicine, Endocrinology Unit, Faculty of Medicine, Mansoura University.

Email

naglaaabass1234@yahoo.com

City

-

Orcid

-

Volume

25

Article Issue

1

Related Issue

28782

Issue Date

2022-03-01

Receive Date

2021-12-31

Publish Date

2022-03-01

Page Start

92

Page End

99

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 25_Issue 1_Pages 92-99.pdf

PDF . 263.6kB

Link

https://scumj.journals.ekb.eg/article_211745.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=211745

Order

9

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Study of Serum Spexin Level in Obese and Non-Obese type 2 Diabetic Patient

Details

Type

Article

Created At

22 Jan 2023