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124698

Diagnostic Value of Estimating the Ratio of Serum Free Triiodothyronine to Free Thyroxine in Differenti-ating Graves' Disease from Thyroiditis

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Last updated: 04 Jan 2025

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Abstract

Background: As the treatment approaches of Graves' disease (GD) and thyroiditis are different, the differential diagnosis is essential. Aim: To assess the diagnostic value of free triiodothyronine (FT3) to free thyroxine (FT4) ratio for differentiation between GD and destructive thyroiditis. Subjects and Methods: The present study was conducted on 100 newly diagnosed thyrotoxicosis patients; 61 with thyroiditis (group 1) and 39 with GD (group 2) and 20 healthy, age-matched subjects representing a control group (Group 3). All participants underwent medical history taking and clinical examination, serum levels of thyroid-stimulating hormone (TSH), FT3, and FT4 were measured, Technetium 99m thyroid Scan was done to all recruited patients. Results: The present results recorded significant increases in FT3, FT4, and decreases in TSH levels in Graves' disease group than in the thyroiditis group. There was a statistically significant difference between the study groups regarding FT3/FT4 ratio, which was lower in thyroiditis group than in Graves' disease group (0.21± 0.03 in group 1 vs 0.35±0.18 in group 2, p-value <0.01), while there was no significant difference between thyroiditis group and the control group. The FT3/FT4 ratio showed a predictive value, with an area under the ROC curve (AUC) of 0.936 (95%CI, 0.876-0.995) for Graves' disease vs. thyroiditis (P < 0.001). Based on the cutoff value of this ratio of more than 0.269 offered a sensitivity of 89.7% and specificity of 91.8%. Conclusion: The results of the present study demonstrated that free thyroid hormones and the FT3/FT4 ratio are useful to differentiate Graves' disease from destructive thyroiditis.
 

DOI

10.21608/scumj.2020.124698

Keywords

Graves’ disease, Thyroiditis, Free Thyroid Hormones, FT3/FT4 ratio

Authors

First Name

Nesma

Last Name

Ibrahim

MiddleName

A

Affiliation

Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt,

Email

dr_nesmali@med.asu.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Hamam

MiddleName

M

Affiliation

Department of Internal Medicine, Armed Forces College of Medicine (AFCM), Cairo, Egypt.

Email

ahm.hamam@yahoo.com

City

-

Orcid

-

Volume

23

Article Issue

2

Related Issue

18442

Issue Date

2020-10-01

Receive Date

2020-11-22

Publish Date

2020-10-01

Page Start

135

Page End

142

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 23_Issue 2_Pages 135-142.pdf

PDF . 341.4kB

Link

https://scumj.journals.ekb.eg/article_124698.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=124698

Order

4

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Diagnostic Value of Estimating the Ratio of Serum Free Triiodothyronine to Free Thyroxine in Differenti-ating Graves' Disease from Thyroiditis

Details

Type

Article

Created At

22 Jan 2023