A biotic stresses (salinity, drought, improper temperature, flooding, metal toxicity, ozone, UV-radiations, herbicides, etc.) remain the greatest constraint to crop production worldwide. It has been reported that more than 50% of yield reduction is the direct result of a biotic stresses. A field experiment at Sakha Research Station Farm , Kafr El-Sheikh, Egypt was carried out during two successive winter seasons 2012/2013 and 2013/2014 to study the role of some bio-chemical in alleviation of soil salinity hazard and improving oilseed rape production. A split plot design with three replicates was performed. The main plots were occupied by different amendments: control (T₁), humate (T₂), Si (T₃), biotol (T₄), humate + Si (T₅), humate + biotol (T₆), Si + biotol (T₇) and humate + Si + biotol (T₈). Whereas, sub plots were the method of application: foliar, soil and foliar + soil application. The results showed that T₈, treatment (humate + Si + biotol) clearly improved the electric conductivity (EC), sodium adsorption ratio (SAR) and exchangeable sodium percentage (ESP), where their values were decreased by 16.9 %, 13.5% and 9.5%, respectively. However, CEC was increased with different amendments as compared to the control in both growing seasons. The highest increase of CEC value (7.4%) was recorded with T₈. The results also revealed that the rape yield and its attributes affected significant by different treatments. The highest increases of seed, oil and protein yields (229.7 %, 250 % and 374 %, respectively) were achieved with T8 (mean of both seasons). The application methods of the ameliorators are affected significantly on their impacts and the foliar + soil application was the best method. The seed yield, protein and oil content were highly significantly increased with the interaction between the ameliorators and methods of application in saline soils. Silicon alleviate salt stress and increased the yield of rape oilseed, whereas the humate improved physical, chemical and biological properties of soil and the uptake of macro- and micro-nutrients and finally increased the yield. Economic evaluation recorded the highest values 11276.6, 75560, 2.42 and 2.0 for total income (LE ha.^-1), net income (LE ha.^-1) , Net income from water unit (LE m^-3)  and economic efficiency, respectively with T₈. It could be concluded that the alleviation of soil salinity and sodicity stress of salt-affected soils can be achieved by foliar and/or soil application of Si+ +humate + biotol.