Effects of mineral fertilization (NPK) rates and foliar application of micro nutrients (Zn, Fe and Mo) on vegetative growth, yield and some nutrient contents of lettuce plant (Lactuca sativa L.) were studied at the Experimental Farm of Faculty of Agriculture, El-Mansoura University during the winter season of 2015. The experiment was conducted in split plot design with three replicates, which were simple possible combination between 3 rates of NPK (50, 100 and 150% of the recommended dose (RD) by the Ministry of Agriculture i.e. 60, 27.5 and 17.43 kg ha^-1 for N, P and K, respectively) as main plots and 4 treatments of micro nutrients foliarly (0, 50 mgL^-1 Mo, 100 mgL^-1 Zn and 300 mgL^-1 Fe) as sub plots. The results acquired from the study demonstrated that, fresh and dry weight as well as yield of lettuce plants increased significantly in response to rate of 100% RD from NPK. In addition; chlorophyll content, N, P, K concentrations, Mo content and NO₃-N concentration in outer, inner leaves and stem recorded the highest values due to 150% of NPK recommended dose (RD), whereas Zn, Fe and nitrate reductase activity were decreased with increasing rate of NPK fertilization. The highest mean values of the grown parameters of lettuce plant significantly increased due to the foliar application of Mo at rate of 50 mgL^-1. Zn, Fe and Mo contents in plant increased due to the foliar application of chelating-Zn at rate of 100 mgL^-1, chelating-Fe at rate of 300 mgL^-1 and chelating-Mo at rate of 50 mgL^-1. As for NO₃-N concentration in outer, inner leaves and stem gave the highest values with foliar of chelating-Zn at rate of 100 mgL^-1.