This study aimed to apply the sesame integrated weed management using tillage accompanied with soil mulching to avoid the plant injuries due to the mechanical weeding and the herbicides environmental side effects. The experiment was established and designed statistically as a split plots with three replications. The main plots involved tillage treatment levels of rotary plough as a minimum tillage, moldboard plough followed by disc harrow and chisel plough (two perpendicular passes) followed by disc harrow as a conventional tillage. The sub plots included soil mulching treatment levels of black, white and transparent polyethylene sheets (30 micron thick), comparing with bare soil. The results indicated that the rotary plough accomplished the higher actual field capacity of 0.92 fed/h and the lower specific energy requirements of 25.43 MJ/fed. While, the moldboard plough followed by disc harrow achieved the moderate soil mean weight diameter of 84 mm. The moldboard plough followed by disc harrow system accompanied with the transparent polyethylene sheet achieved the higher values of both the soil moisture content and the weed control efficiency at the periods of 7, 30 and 60 days after planting. Also, it recorded the higher sesame seed yield of 1.26 ton/fed. So, it is recommended to apply the moldboard plough followed by disc harrow and accompanied with the transparent polyethylene sheet as a proper sesame weed control method.