Laboratory studies were carried out to investigate the efficiency of three anticoagulant rodenticides ,Brodifacoum, Chlorophacinon, and Warfarin on both sexes of albino  house mouse  Mus musculus L. which fed on either mixture of churched maize and wheat or vegetables. The gained results revealed that the LD30,LD50 ,LD90,values of Brodifacoum were respectively; 0.235 ,0.46 and 2.385 mg/kg bw for males and were o.284 ,0.556 ,and 2.872 mg/kg of b.w. for females of albino house mouse, Mus musculus which have been fed on mixture of churched maize and wheat. These values were respectively ,0.175,0.407and 3.018 mg/kg of b. w. for males which have been fed on vegetables, while they were o.184,0.417 and 3.273 mg/kg of b.w. for females. The LD30,LD50, and LD90 ,of Chlorophacinone for  albino house mouse Mus musculues which were fed on maize and wheat were 7.932, 22.39 and 178.823 mg/kg of b.w. for males but they were 8.155, 22.677 and 26.142 mg/kg b.w. for  females ,while in case of vegetables they were 8.401,20.312 and175.111 mg/kg of b.w for males, but they were 8.796 ,21.538 and 215.299 mg/kg b.w.for females respectively. The LD30, LD50 and LD90 of Warfarine for albino house mouse Mus musculus when fed on vegetables they  were e 133.832,380.419 and 4887.439 mg/kg b.w.for  males while theywere175.50,407.894 and 5203.665 for females. Meanwhile , when the mice  fed on mixture crush maize with wheat they were 133.832, 380.419 ,and4887.439 mg/kg  for mages  and they were  175.507 ,407.894 and 5203.894 mg/kg of b. w. for females. In additional; the figures proved that the experimental mice which were fed on mixture of crushed maize and wheat were more tolerant to warfarine compound (LD50 valuse of males 280.419  and females 407.894 mg/kg of b. w.). Meanwhile, they were more susceptible to Brodifacoum (LD50 value of male, 0.407 and female,0.417 mg/kg of b.w.). Also the results cleared that male of the house mouse were more susceptible than female for each of brodifacoum, Chlorophacinon and Warfarine . The animals which have been fed on vegetables took the same trend . At last the mice which were fed on vegetables were more tolerant than which were fed on mixture of crushed wheat and maize.