This study aimed at investigating the effects of flavomycin (F) at 40 and 20 mg/h/d and monensin (M) at 20 and 10 mg/h/d on growing Barki ewe lambs. These additives were added to a nutritional level for 100 g daily gain. Other treatment was included which was a high level feeding (HL) covering the requirements of growth rate of 150 g/d. The hematological status and liver function were studied. Sixty Barki ewe lambs, averaged 140.3 + 1.12 days old and 20.6 + 0.37 kg live body weight, were randomly allotted on six groups including the control (C). According to the treatments, these groups were symbolized as C, F40, F20, M10, M20 and HL groups. The treatments lasted 7 months. At the end of the experimental period, the two flavomycin treatments resulted in the lowest (p < 0.01) values of RBCs (8.6 and 7.4 x 10⁶/mm³), while the control and HL groups showed higher values in the range from 10.3 to 14.1 x 10⁶/mm³. Overall means of WBCs for all groups throughout the whole period were confined in a narrow range from 10.23 to 12.00 x 10³/mm³, indicating that treatments did not cause any inflammations. The F20 and F40 groups had the lowest (p < 0.05) mean hemoglobin (11.4 g/dl) while the other groups had values lied between 12.1 and 12.8 g/dl. The lowest overall mean of packed cell volumes were those of F20 and F40 groups (29.4 and 30.6%, respectively). High level feeding and monensin treatments kept this parameter (31.3% to 32.9%) near its level in the control group (32.4%). All treatments resulted in increasing the overall means of the corpuscles' volume (31.3 to 32.6 fl) as compared with that of the control group (28.7 fl). Flavomycin treatment led to increase the concentration percentage of hemoglobin within the red corpuscles. There were no differences in plasma total protein between treated and control groups. The overall mean along the experimental period was 6.2 g/dl. The values of albumin (A) and globulin (G) in the experimental ewe lambs indicated that the changes in plasma protein during growth stage were mainly due to alteration in plasma albumin. The experimental groups had no significant (p < 0.05) differences in A/G ratio. The values of aspartate amino transferase (AST) enzyme were in the normal range of growing animals, either at the end (25.4 – 40.3 IU) or throughout the entire experimental period (29.1 to 34.4 IU). The values of alanin amino transferase (ALT) enzyme increased at the end of the experimental period (21.2 to 28.4 IU) indicating liver hyper function due to higher metabolic rate as the ewes began to get pregnant. The results indicate that flavomycin and monensin can be used safety in growing ewe lambs in order to enhance their growth rate.