Two field experiments were carried out at Rice Research and Training Center, Sakha, Kafr El-Sheikh, Egypt during 2018 and 2019 cropping seasons. Experiments aimed to determine the impacts of different deficit irrigation treatments on the available soil nutrients, N, P, K and Zn uptakes, rice yield and water use efficiency. The field experiments were laid out in a strip-plot design with four replications. The horizontal plots were devoted to the four irrigation treatments: continuous submergence (W1), intermittent irrigation at 6-day intervals (W2), intermittent irrigation at 9-day intervals (W3) and intermittent irrigation at 12-day intervals (W4), while vertical plots were occupied by the three rice genotypes, namely Giza 177, Giza 179 and GZ10154. Intermittent irrigation at 6-days intervals (W2) treatment, recorded the highest available NH₄⁺-N, NO₃^--N and K concentrations in the soil. The highest values of available-N and available-P concentrations in the soil were obtained with (W1) while (W4) recorded the lowest values. The N, P, K and Zn uptakes were significantly affected by the prolonged irrigation intervals. Rice yield and its attributes decreased significantly as irrigation intervals increased up to 12-day (W4) in both seasons. The highest values of plant height, number of panicles m^-2, panicle weight (g), 1000-grain weight (g), number of filled grains panicle^-1, grain and straw yields were obtained with (W1) followed by (W2) treatment, except panicle length and number of unfilled grains panicle^-1 in both seasons. Water saved (%) ranged from 8.90% to 26.46% and from 17.47% to 27.25% in 2018 and 2019 seasons, respectively.