The study aimed to investigate the adoption of Veterinary Vaccines Technique (VVT) among Sheep Raiser's (SR) of Matrouh Governorate through achieving the following objectives. 1) To identify the adoption phases of VVT among SR of Matrouh Governorate. 2) To recognize the relationship between the personal characteristics of SR and the adoption of VVT among respondents. 3) To determine the personal characteristics contribution in explaining the variation of the adoption of VVT among respondents .This study was carried out in Matrouh Governorate. A simple random sample of 282 respondents was selected from SR's lists representing (26.0%). Four villages were selected for this study as follow: El-grawla, Sedi henash, El-zayat, El- halazeen, whereas numbers of respondents were 96, 78, 77, and 31 respectively. Data were collected during the period from August 2020 to October 2020. Frequency, percentage, mean, standard deviation, and relative weight were used for descriptive purposes. The Pearson correlation coefficient was employed to explore the relationship between the personal characteristics of SR and the adoption of VVT. Step-wise regression was utilized to determine the contribution ratio of each independent variable in explaining the determination coefficient of the adoption of VVT. All statistics were carried out using SPSS package. Results showed the respondents distribution among the adoption phases as follows: (95.8%) of the total respondents are located in the awareness stage, (95.8%) in the interest stage, (86.5%) in the evaluation stage, (79.2%) in the trial stage, (75.0%) of the total respondents in the post-trial evaluation stage, while, (70.8%) of the study respondents adopted the improved idea under study. Finally, (63.8%) of the total respondents continues to practice VVT. The results showed positive and significant correlation at 0.01 levels between the SR adoption degree of VVT and the following variables: Size of the agricultural animal possession, Size of the sheep-animal agricultural possession, Formal social participation, Urban frequent visitations, Participation in extensional training programs, Motives for participating in developmental extension activities, and Frequent visitations of Districts that provide agricultural services.