A total number of 90 APRI rabbits at 5 weeks of age were divided into nine treatments, 10 rabbits each, to investigate the effect of different dietary digestible energy (DE) and crude protein (CP) levels in a 3x3 factorial design on rabbits growth performance, carcass traits, blood plasma constituents and nutrients digestibility during the fattening period (5-13 weeks of age ). Rabbits were fed different three levels of DE 2500, 2600, and 2700 kcal DE/kg diet each with 14, 16 and 18 % CP level. The results showed that the highest body weight, daily weight gain and growth performance were obtained with 2600 Kcal DE/Kg diet followed by those fed diet containing 2500 KcalDE. Increasing dietary protein to 16% CP significantly increased live body weight, daily weight gain, growth performance and performance index and improved feed conversion ratio. There were no significant effect due to DE or protein levels on digestibility coefficient of DM, OM, EE and NFE, while fiber digestibility coefficient decreased with increasing DE. Crude protein digestibility coefficient increased by increasing protein level. There were no significant effect on plasma constituents due to energy levels except in case of triglycerides and cholesterol. CP levels affected significantly on total protein, albumin, globulin and creatinine. Increasing CP increased total edible parts, while no significant differences could be detected due to DE levels. Meat content of DM, CP and EE were increased by increasing DE and protein level. In conclusion the optimal protein and energy levels for APRI rabbits in the present study are 16% CP with 2500 kcal DE/kg diet to maximize the productive performance and economic efficiency.